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KMID : 1123920090230061404
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Korean Journal of Oriental Physiology and Pathology
2009 Volume.23 No. 6 p.1404 ~ p.1408
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Effects of Rubus Coreanus Miquel on the Apoptosis of U937 Cells
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Lee Kwang-Gyu
Han Jong-Hyun
Oh Chan-Ho
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Abstract
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Methanol extracts of Rubus Coreanus Miquel (RCM) were found to exhibit apoptosis induction of U937 human histiocytic leukemia cells. Treatment of RCM exerted strong cytotoxicity against U937 human leukemia cells. RCM induced apoptosis of U937 leukemia cells in a dose dependent manner. Nitric oxide (NO) production was increased in RCM-treated RAW264.7 macrophage cell line. RCM increased the p53 and NFκB gene and decreased the IκB gene expression in U937 cells. RCM also increased the NFκB protein expression, but decreased the PCNA and BcL-xL protein expression in cultured U937 cells. These data suggest that RCM are effective on the apoptosis induction of human leukemia cells and anti-cancer properties.
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KEYWORD
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Rubus Coreanus Miquel, apoptosis, p53, NFκB, BcL-xL, PCNA
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